To advance heart disease research and the creation of more stable and functional heart tissues, University of Toronto researchers have incorporated crucial immune cells into heart-on-a-chip technology, transforming the study of heart conditions and the development of new health care solutions.
Utilizing state-of-the-art lab facilities, researchers have developed an innovative technology that leverages immune cells derived from human stem cells, known as primitive macrophages to create bioengineered heart tissue. Their work reveals that these macrophages play a vital role in forming a stable and functional network of blood vessels, addressing a major challenge in the development of engineered heart tissues.
By enhancing the functionality and stability of engineered heart tissues, researchers can better study heart diseases and test new drugs that could lead to more accurate disease models and more effective treatments for heart conditions.
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